منابع مشابه
Mechanisms of plaque formation and rupture.
Atherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), or lower extremities (peripheral vascular disease). The most common of these manifestations is coronary heart disease, including stable angina pectoris and the acute coronary syndromes. Atherosclerosis is a lipopro...
متن کامل4 Atherosclerotic plaque rupture
The arterial system is more than an intricate plumbing system for the transport of blood; it is a highly complex organ that interacts with its environment. The major function of the vessel wall, and more specifically the endothelial lining, is to maintain an adequate blood supply to the end organ that it is supplying. This is achieved by regulatory mechanisms that control vascular tone, inflamm...
متن کاملAtherosclerotic Plaque Rupture
The idiom “the straw that breaks the camel’s back” describes scenarios where seemingly minor incidents eventuate in a sudden, unexpected, and often detrimental downfall. In the case of atherosclerosis, over time multiple subclinical cellular events result in the development of unstable, vulnerable atherosclerotic lesions, which leads to the rupture of atherosclerotic plaques, culminating in the...
متن کاملAtherosclerotic Plaque Rupture
It is generally established that the unstable plaque is the major cause of acute clinical sequelae of atherosclerosis. Unfortunately, terms indicating lesions prone to plaque instability, such as “vulnerable plaque,” and the different phenotypes of unstable plaques, such as plaque rupture, plaque fissuring, intraplaque hemorrhage, and erosion, are often used interchangeably. Moreover, the diffe...
متن کاملPlaque rupture: plaque stress, shear stress, and pressure drop.
tenosis (1). The Hypertension Genetic Epidemiology Network HyperGEN) Study Group conducted a genome-wide linkage can on aortic valve sclerosis (2) that deserves to be discussed. This yperGEN cohort was a substudy of a larger National Heart, ung, and Blood Institute program, the Family Blood Pressure rogram, designed to search for hypertension/blood pressure enes. The authors reported familial a...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2000
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.39.335